I was wondering how submitted molecules are being evaluated for synthetic feasibility? Is retrosynthetic analysis being used? Is a preliminary filter of synthetic accessibility being used? (eg the Ertl approach https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3225829/)
When a compound is submitted, PostEra searches a variety of chemical databases to see if that compound is available – these are automatically flagged on the submission. If the compound is not commercially available, PostEra uses our retrosynthetic tools, which are machine-learning based models, to design synthetic routes. This also acts as a filter for what compounds Moonshot sends to our CRO partners. However, I would add that if the submission is particularly interesting we may also send if for synthesis even if the synthetic complexity is high.
So yes, we use retrosynthetic analysis (plus human input on especially difficult molecules) not just a synthetic complexity score.