Submission PET-UNK-c9c1e0d8

Topic automatically created for discussing the designs at:
https://covid.postera.ai/covid/submissions/PET-UNK-c9c1e0d8

Thanks @pwkenny,

I’ll note that JAN-GHE-83b26c96-12 and TRY-UNI-714a760b-6 were already assayed and showed very little difference in IC50 from the Cl --> Br change

Would you expect any difffernce due to the pyridine --> isoquinoline change?

Thanks, Matt, I would anticipate similar [Cl->Br] differences for the pyridine and isoquinoline and I would suggest not synthesizing the bromophenyl analog for the isoquinoline at this stage. I had included it as something that needed to be checked and the results for pyridine (of which I’d been unaware) provide the necessary information.