Submission PET-UNK-5ecb6237

Topic automatically created for discussing the designs at:
https://covid.postera.ai/covid/submissions/PET-UNK-5ecb6237

I’ll mention @mc-robinson and @londonir (this submission is analogous to NIR-WEI-75ed5c39). While there are not enough examples in the Cambridge Structural Database (CSD) to permit meaningful statistical analysis of torsional distributions, entries POKFON POKGEE WUCXUN suggest that substitution of anilide nitrogen with nitrile will not ‘invert’ the amide cis/trans geometrical preference in the same way that substitution with sp3 carbon does.