Topic automatically created for discussing the designs at:
https://covid.postera.ai/covid/submissions/MIC-UNK-67d4a29a
I would anticipate that N-methylation of the amide will still result in a signifcant loss of potency as noted in a comment on the MAK-UNK-3875bbc8 submission: “Comparison of IC50 values for MAT-POS-bb423b95-7 and ADA-UCB-6c2cb422-1 suggests that methylation of the amide nitrogen in the 3-amino series will result in a signficant reduction in potency. This is likely to result from a shift in the cis/trans geometrical preference of the amide as discussed here.”