Topic automatically created for discussing the designs at:
https://covid.postera.ai/covid/submissions/MAT-POS-2db6411e
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3-methylindole on LHS risks kicking out N-heterocycle
… after all that!!!
we see this all the time on our p53 project… sorry!
Still, it forms a Michael acceptor product, but likely would show high HepG2 tox.
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Ahh, devastating! Interesting catch @JSPEN, I have a feeling this design pattern may show up quite a bit, so something to look out for.
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