Topic automatically created for discussing the designs at:
https://covid.postera.ai/covid/submissions/MAK-UNK-3875bbc8
Comparison of IC50 values for MAT-POS-bb423b95-7 and ADA-UCB-6c2cb422-1 suggests that methylation of the amide nitrogen in the 3-amino series will result in a signficant reduction in potency. This is likely to result from a shift in the cis/trans geometrical preference of the amide as discussed here.
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