Submission JOH-UNI-6e27fddc

Topic automatically created for discussing the designs at:

Hi @JSPEN I’d been thinking of cyanoamidines a while back with a view (I concluded that the idea was overly optimistic and abandoned it) of targeting the backbone carbonyl oxygen of GLU166 with the nitrile carbon. Nevertheless, I think cyano may offer advantages (physicochemical; synthetic) over di/trifluoroethyl as an amidine substituent. I’ll include @edgriffen in the discussion since he’s been thinking about conformational effects of substituents at C5 in EDJ-MED-d1555997.