Topic automatically created for discussing the designs at:
https://covid.postera.ai/covid/submissions/JOE-NOR-4e4adc6b
Hi @Joe, benefits of the cyclopropane are believed to due to improved ADME characteristics. Sometimes the inhibitors with the cyclopropane linker are more potent than their methylene-linked analogs and sometimes it’s the other way round. Generally the potency differences are small.