Submission EDJ-MED-6b23330e

Topic automatically created for discussing the designs at:

Hi @edgriffen @mc-robinson @alphalee, I’d recommend that you consider including the primary amide in this set (MAT-POS-4223bc15-25 and MAT-POS-4223bc15-23 are essentially equipotent). While one might anticipate that the primary amide would be chemically less stable, amide hydrolysis and active efflux in vivo are catalytic processes and the primary amide may be a less effective substrate than the secondary amides.