Topic automatically created for discussing the designs at:
https://covid.postera.ai/covid/submissions/ED_-GRI-5b13fbe2
Hi Ed @edgriffen,
I think that it would be a good idea to check the potency for the structural prototype PET-UNK-29afea89-2 before synthesizing any of these. There are acidic and basic centers in the molecular structures of a number of the designs and I would question how effectively the the S1’ subsite is likely to recognize anionic and cationic groups. Here’s a comment on basic centers from some discussion with @RGlen on the DAR-DIA-5ff57136 designs submitted by @Daren_Fearon