PostEra

Submission DAR-DIA-033

https://covid.postera.ai/covid/submissions/03336633-0419-4378-aa8c-c224dced95b6

These are quite interesting designs; however, I believe most are somewhat difficult to synthesize – especially at the speeds we require.

I’ll post an example route to DAR-DIA-033-2, as an example.

This initial substructure should be doable by this urea formation reaction Screen Shot 2020-03-17 at 12.57.29 AM

We we see that EN300-708755 can take part in “formation of urea” for an easy synthesis.

Next the algorithm would have us perform a Negishi; however, I don’t believe either the Negishi or the preparation of the organozinc would be particularly quick to perform. Screen Shot 2020-03-17 at 1.02.23 AM

We can certainly check with Enamine. I will also comment on the other molecules when I wake up tomorrow!