PostEra

Expansion of gene networks related to Covid

COVID General
#1

Hi all, not a scientist myself, so my contribution in this forum will be limited to this topic. I am a distributed computer volunteer, and I knew Postera thanks to the Folding@Home forum.
I’d like to signal to you another project which worked on Sars-Cov2 and as far as I know their work on the virus is completed. It’s called Tn-Grid and they performed the “expansion of gene regulatory network” (I don’t know what it is) on all the genes believed to be related to the virus. Some of these genes are:
ACE2 AGT AGTR1 AGTR2 REN MME DPP4 PRCP MEP1B MEP1A XPNPEP2 MME DPP4 BRD2 INS GIP SLC5A2 SLC5A5 ADA GCG GLP1R PTPRC CD28 CCR7 PDCD1 SNCA SPATA2 CD27 B3GAT1 IL7 IL2RA ISG20 FAS PTPN13 CD38 CD74 CD24 CR2
the total number is 1242
If someone of you think it can be of any help, I think you should contact them. They are a group of researcher at Università di Trento, Italy.

Post about covid: https://gene.disi.unitn.it/test/forum_thread.php?id=265
Website: https://gene.disi.unitn.it/test

#2

Thanks for the post here; I for one wasn’t aware of the their work. It seems their work becomes very useful when deciding which target or biological pathway to select for then developing a therapy to combat SARS-COV-2. In Moonshot’s case, all our work has been focused on a single target – inhibiting the main protease, a key enzyme involved in viral replication, and our emphasis right now is on experimental testing of compounds rather than looking for new targets. But we’ll certainly bear their work in mind.

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