mc-robinson
For ANT-DIA-3c7-1, Our technology finds the following route from Enamine’s building blocks: It should be an easy one step reaction ready to send off.
For ANT-DIA-3c7-1, Our technology finds the following route from Enamine’s building blocks: It should be an easy one step reaction ready to send off.
For ANT-DIA-3c7-2,
We again find a simple one step amidation from Enamine building blocks.
ANT-DIA-3c7-3 is a bit harder. Our algorithm finds two routes, one involving two steps with a SNAr and the other using two steps with a Buchwald-Hartwig. Unfortunately, neither is amenable to highly parallel chemistry.
This one may need a slight redesign – can work on tomorrow.
And ANT-DIA-3c7-5 should be do-able, though probably less easy than 1,2,4. One can also start with the Chlorinated, or Brominated species, but the SNAr I think works best with the fluorine species.
Sorry the routes are so ugly, I was running locally to integrate Enamine’s data quickly
