PostEra

Submission DAR-DIA-5ff57136

Hi Daren,

The data in the NMR study show that the cis/trans preference of acetanilides can be modulated by tuning the electronics of the benzene ring (although not to the extent that the conformation with benzene syn to carbonyl oxygen predominates). While molecules can be forced into ‘unnatural’ conformations, this needs to be done in a manner that doesn’t compromise affinity.