Hi, thank you for your submission! Just wanted to note that I have concerns regarding the geminal diols in NEL-UNI-146-1,2,3,4. I am almost sure they will not be stable! If you have reason to think otherwise, let me know. Thanks, Matt
1 reply
Matt,
Yea I believe you are right, I am not sure how I overlooked that… I suppose I was just focusing on interactions with residues on the enzyme and not thinking about stability of the molecule enough. My experience is more on the protein engineering side, not making drugs, so I appreciate your insight.
Thanks,
Nels