Hi @JSPEN, yes we hope to get a structure as soon as the beamline gets back up early September. And good point, we had suspected it may be forming disulfide bonds, but I didn’t recognize the similarity to proton pump inhibitors
Hi @xtaldave, sorry this one got lost in my notifications. Unfortunately, the initial results from Rapidfire was completely flat.
I believe there was some concern over that protein batch, and re-synthesis of the compound was already being performed at Enamine. So we should know more after re-testing in both assays this week.
-Matt